Key result
Annotation of the Drosophila pseudoobscura slmb ortholog identifies three highly conserved protein-coding isoforms.
Why the study?
This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway across the genus Drosophila.
Provides a gene model for the slmb ortholog in Drosophila pseudoobscura to aid in studying the evolution of the insulin signaling pathway.
Answers are grounded in this paper and cite their sources.
Extends Drosophila genomics resources; leaves open functional validation in vertebrate disease models.
Gene model for the ortholog of supernumerary limbs ( slmb ) in the Apr. 2013 (BCM-HGSC Dpse_3.0/DpseGB3) Genome Assembly (GenBank Accession: GCA_000001765.2) of Drosophila pseudoobscura . This ortholog was characterized as part of a developing dataset to study the evolution of the Insulin/insulin-like growth factor signaling pathway (IIS) across the genus Drosophila using the Genomics Education Partnership gene annotation protocol for Course-based Undergraduate Research Experiences.
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Lawson et al. (2026) studied this question. A gene model for the Drosophila pseudoobscura ortholog of the Drosophila melanogaster supernumerary limbs (slmb) gene was characterized, identifying three highly conserved protein-coding isoforms.
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