Key result
In patients without diabetes, the apnea-hypopnea index was independently associated with fasting GLP-1 (β = 0.31; P = 0.0019) and post-prandial GIP (β = -0.21; P = 0.037).
Observational (n=96)
Obstructive sleep apnea is associated with elevated fasting GLP-1 and post-prandial GIP levels in patients without diabetes, which may influence fasting glucose levels.
OSA severity may alter incretin levels in nondiabetics; hypothesis-generating for glucose effects, needs prospective validation.
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Matsumoto et al. (2016) conducted an observational in Obstructive Sleep Apnea (n=96). Obstructive sleep apnea (apnea-hypopnea index) vs. Normal to moderately severe OSA was evaluated on Fasting GLP-1 and IAUC GIP serum levels (β = 0.31 for fasting GLP-1, p=0.0019). In patients without diabetes, the apnea-hypopnea index was independently associated with fasting GLP-1 (β = 0.31; P = 0.0019) and post-prandial GIP (β = -0.21; P = 0.037).
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