Key result
Nitric oxide exhibits a dual role in cancer biology, mediating both oncogenic signaling pathways and antioncogenic, proapoptotic actions.
This review highlights the dual role of nitric oxide in cancer biology, including its oncogenic signaling pathways and proapoptotic actions.
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Nitric oxide modulation in cancer requires context-specific caution; leaves open prospective trials to define therapeutic windows.
The dual role of nitric oxide in cancer biology is discussed here through the perspective of our work on nitric oxide−mediated signaling events. The nitric oxide-stimulated Src-FAK and Ras-ERK1/2 mitogen-activated protein kinases (MAPKs) oncogenic signaling pathways are discussed, highlighting the cross-talk between 2 major posttranslational modifications: protein phosphorylation and protein S-nitrosylation. In addition, we discuss the importance of nitric oxide synthases in cancer biology, focusing on the roles of endothelial nitric oxide synthase and arginase 2 in human thyroid tumor progression. A direct relationship between the expression levels of both enzymes was found in human follicular thyroid carcinoma. Finally, the antioncogenic, proapoptotic actions of nitric oxide based on its anti-adhesive properties are presented and discussed.
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Oliveira et al. (2012) conducted a review in Cancer. Nitric oxide and nitric oxide synthases was evaluated. Nitric oxide exhibits a dual role in cancer biology, mediating both oncogenic signaling pathways and antioncogenic, proapoptotic actions.
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