Keeping the CO pressure down is a crucial, practical feature of the new methodology for the carbonylation of terminal epoxides. β-Hydroxy morpholinyl amides are generated directly in optically pure form [Eq. (1)], and these building blocks can be applied in a variety of acyl transfer reactions. A useful illustration is provided in the concise synthesis of δ-hydroxy-β-ketoesters, key intermediates for the preparation of the statin class of HMG-CoA reductase inhibitors.
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Goodman et al. (2002) studied this question.