Levamisole and Chronic Delta Hepatitis

Letters and Corrections1 June 1983Levamisole and Chronic Delta HepatitisARRIGO ARRIGONI, M.D., ANTONIO PONZETTO, M.D., GIOVANNI ACTIS, M.D., FERRUCCIO BONINO, M.D.ARRIGO ARRIGONI, M.D.Search for more papers by this author, ANTONIO PONZETTO, M.D.Search for more papers by this author, GIOVANNI ACTIS, M.D.Search for more papers by this author, FERRUCCIO BONINO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-98-6-1024_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: A cause of liver damage in carriers of hepatitis B surface antigen (HBsAg) is the newly described hepatitis B virus-associated delta agent (1); delta hepatitis may be a progressive disease, unresponsive to steroids and immunosuppressors (2). We studied whether levamisole, a drug restoring peripheral lymphocyte function in patients with impaired cellular immunity (3), may be beneficial in patients with chronic delta hepatitis.A pilot study was done in 16 carriers of hepatitis B virus with chronic active hepatitis, 8 with intrahepatic hepatitis B core antigen, (HBcAg) and 8 with delta antigen detected by immunofluorescence. Ten patients were...References1. BONINOHOYERFORDWAI-KUOPURCELLGERIN FBESJRJ. The delta agent: HBsAg particles with delta agent and RNA in the serum of an HBV carrier. Hepatology. 1981;1-2:127-31. CrossrefGoogle Scholar2. RIZZETTOVERMERECCHIA MGS. Chronic hepatitis in carriers of hepatitis B surface antigen, with intrahepatic expression of the delta antigen: An active and progressive disease unresponsive to immunosuppressive treatment. Ann Intern Med. 1983;98:437-41. LinkGoogle Scholar3. WYBRANGOVAERTS JA. Levamisole and human lymphocyte surface markers. Clin Exp Immunol. 1977;27:319-21. MedlineGoogle Scholar4. WYBRANFUDEMBERG JH. Thymus derived rosette forming cells in human disease state: cancer, lumphoma, viral and bacterial infection and other diseases. J Clin Invest. 1973;52:1026-32. CrossrefMedlineGoogle Scholar5. RIZZETTOSHIHGOCKEPURCELLVERMEGERIN MJDRGJ. Incidence and significance of antibodies to delta antigen in hepatitis B virus infection. Lancet. 1979;2:986-90. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ospedale Maggiore di San Giovanni Battista e della Città di Torino Corso Bramante 88; 10126 Torino Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByInterferon alpha for chronic hepatitis DHepatitis D virus: an updateNatural history and treatment of chronic delta hepatitisÉpidémiologie, histoire naturelle et traitements de l'infection virale deltaHépatites viralesInterferon-alpha for hepatitis DTraitements des hépatites virales deltaTreatment of hepatitis DEpidemiology of Hepatitis Delta Virus (HDV) Infection in the Dialysis PopulationLamivudine for chronic delta hepatitisHepatitis D VirusAntiviral Chemotherapy for Viral HepatitisLong-term interferon-α treatment of children with chronic hepatitis delta: a multicentre studySection Review: Anti-infectives: Recent developments in the treatment of hepatitis D infectionInterferon in HDV infectionDelta hepatitis: molecular biology and clinical and epidemiological featuresLoss of HBsAg with interferon-α therapy in chronic hepatitis D virus infectionInterferon therapy of chronic delta hepatitis in patients cured of pediatric malignancies: possible harmful effectA randomized controlled trial of a 12-month course of recombinant human interferon-α in chronic delta (type D) hepatitis: A multicenter Italian studyHepatitis Delta Virus: Infection and DiseaseDie Therapie der chronischen Virushepatitis — Ein noch ungelöstes Problem mit neuen PerspektivenChronic hepatitis: Pathogenesis and treatmentDelta Agent HepatitisTreatment of chronic delta hepatitis with α-2 recombinant interferonHepatitis B Markers in United States Drug Addicts with Special Emphasis on the Delta Hepatitis VirusThe Delta Agent 1 June 1983Volume 98, Issue 6Page: 1024-1024KeywordsAntigensHepatitis BHepatitis DHepatitis D virusImmunofluorescenceLiverLymphocytesPilot studiesProgressive diseasesSteroids Issue Published: 1 June 1983 PDF DownloadLoading ...