"Restless Legs" Syndrome in Acute Intermittent Porphyria

Case Reports1 March 1962"Restless Legs" Syndrome in Acute Intermittent PorphyriaEMANUEL S. HELLMAN, M.D., DONALD P. TSCHUDY, M.D.EMANUEL S. HELLMAN, M.D.Search for more papers by this author, DONALD P. TSCHUDY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-3-487 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA syndrome of unpleasant paresthesias, predominantly in the lower extremities, and the resultant voluntary, restless, twitching motions on the part of the sufferer to obtain relief, was probably first noted by Willis in 1685 (1). Attention was redirected to this sympton complex by Ekbom in 1944 and in his subsequent publications (2-4) where he applied the term "restless legs" to this syndrome. "Restless legs" developing in a patient with acute intermittent porphyria is presented and documented as yet another symptom in a disease of protean manifestations.CASE REPORTThe patient was a 58-year-old white male former machinist. Hypertension, apparently labile...References1. WILLIS T: The London Practice of Physick, 1st ed., Thomas Basset and William Crooke, London, 1685, p. 404. Google Scholar2. EKBOM KA: Asthenia crurum paraesthetica (irritable legs). Acta Med. Scand. 118: 197, 1944. CrossrefGoogle Scholar3. EKBOM KA: Restless legs. Acta Med. Scand. (Supp.) 158: 1, 1945. Google Scholar4. EKBOM KA: Restless legs syndrome. Neurology 10: 868, 1960. CrossrefMedlineGoogle Scholar5. JOLIVET B: Paresthesies agitantes nocturnes des members inferieurs, impatiences. These de Paris, 1953. Google Scholar6. ASK-UPMARK E: Contribution to the pathogenesis of the syndrome of restless legs. Acta Med. Scand. 164: 231, 1959. CrossrefMedlineGoogle Scholar7. BRENNING R: Restless legs; forsok till patogenetisk forklaring. Svensk. Lakartidn. 54: 2293, 1957. MedlineGoogle Scholar8. SIMONS AJ: On paresthesia. Thesis, Utrecht, 1951. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Bethesda, MarylandFrom the Metabolism Service, National Cancer Institute, National Institutes of Health.Requests for reprints should be addressed to Donald P. Tschudy, M.D., National Cancer Institute, National Institutes of Health, Bethesda, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIh contributes to increased motoneuron excitability in restless legs syndromeAcute-onset Restless legs syndrome in acute neurological conditions-a prospective study on patients with the Guillain-Barre syndrome and acute strokePERIODIC LIMB MOVEMENTS AND RESTLESS LEGS SYNDROMESPONTANEOUS LEG CRAMPS AND “RESTLESS LEGS” DUE TO DIABETOGENIC HYPERINSULINISM: OBSERVATIONS ON 131 PATIENTS* 1 March 1962Volume 56, Issue 3Page: 487-489KeywordsHypertensionLesionsPorphyriaRestless legs syndromeTachycardia Issue Published: 1 March 1962 PDF downloadLoading ...