Key result
Neoadjuvant chemotherapy followed by surgery for primary pulmonary extraskeletal Ewing sarcoma resulted in 98% tumor necrosis in one patient and no residual tumor in the other.
Case Report (n=2)
No
Neoadjuvant chemotherapy followed by surgery resulted in significant tumor necrosis and complete excision in two cases of rare primary pulmonary extraskeletal Ewing sarcoma.
Adds two cases of rare primary pulmonary EES; leaves open questions on optimal diagnosis and management.
Primary pulmonary extraskeletal Ewing sarcoma (EES)/ primitive neuroectodermal tumor is an extremely rare tumor with only few cases reported in the literature. In this study, we present two cases of primary pulmonary EES diagnosed and treated at our institution. The median age was 20 years (range: 19–21). Cough, dyspnea, and hemoptysis were the predominant features at presentation, associated with a large lung mass on imaging. Image-guided core needle biopsies were the diagnostic modalities for both patients. Initial histopathology showed malignant small round cell tumor, which has been confirmed by immunohistochemistry as EES. Both patients received neoadjuvant chemotherapy followed by surgery; postoperative pathology for the first patient showed 98% tumor necrosis, whereas the second patient’s pathology showed no evidence of residual tumor after complete surgical excision.
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Sobh et al. (2017) conducted a case report in Primary pulmonary extraskeletal Ewing sarcoma (EES)/ primitive neuroectodermal tumor (n=2). Neoadjuvant chemotherapy followed by surgery was evaluated. Neoadjuvant chemotherapy followed by surgery for primary pulmonary extraskeletal Ewing sarcoma resulted in 98% tumor necrosis in one patient and no residual tumor in the other.
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