Key result
Increasing venous filling pressure by transfusion after aortic valve homograft replacement produced a normal increase in stroke work index despite depressed left ventricular function.
Why the study?
Does increasing venous filling pressure by transfusion improve left ventricular function in patients shortly after aortic valve homograft replacement?
Does increasing venous filling pressure by transfusion improve left ventricular function in patients shortly after aortic valve homograft replacement?
Despite depressed baseline left ventricular function shortly after aortic valve homograft replacement, the stroke work index responds normally to increases in left atrial pressure via transfusion.
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Should not yet change post-homograft AVR transfusion practice; hypothesis-generating for preload responsiveness in depressed LV.
Fordham et al. (1967) studied this question. Increasing venous filling pressure by transfusion after aortic valve homograft replacement produced a normal increase in stroke work index despite depressed left ventricular function.