Key result
Linoleic acid preincubated with COX-1 or -2 significantly inhibited prostaglandin formation from arachidonic acid, reducing COX-2 activity to 4.8% of control.
13-HPODE, preformed from linoleic acid by COX reactions, acts as a potent basal suppressor of prostaglandin formation from arachidonic acid, with a stronger inhibitory effect on COX-2 than COX-1.
No clinical recommendations follow from this preclinical inhibition; leaves open human cardiovascular relevance of linoleic acid-COX effects.
Linoleic acid (LA) preincubated with cyclooxygenase (COX)-1 or -2 inhibited prostaglandin (PG) formation from arachidonic acid (AA) catalyzed by the respective enzyme, but LA without the preincubation did not. 13S-Hydroperoxy-9Z,11E-octadecadienoic acid (13-HPODE) a hydroperoxy adduct of LA inhibited PG formation catalyzed by COX-1 or -2. 13S-Hydroxy-9Z,11E-octadecadienoic acid had no effect on both COX-1 and -2 activities. These results suggest that 13-HPODE which is preformed from LA by COX reaction under normal physiological conditions can be a basal suppressor of PG formation from AA.
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Fujimoto et al. (2008) studied this question. Linoleic acid preincubated with COX-1 or -2 (forming 13-HPODE) vs. Control (no preincubation) was evaluated on Prostaglandin formation from arachidonic acid (% of control) (p=<0.01). Linoleic acid preincubated with COX-1 or -2 significantly inhibited prostaglandin formation from arachidonic acid, reducing COX-2 activity to 4.8% of control.
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