Key result
Graves' disease was associated with a significantly higher risk of depression (HR 1.69; 95% CI 1.45-1.96) and higher rates of diabetes (8.03% vs 4.48%) compared to matched controls.
Why the study?
Is Graves' disease associated with an increased risk of depression and cardiovascular comorbidities in Asian patients?
Cohort (n=20,975)
Is Graves' disease associated with an increased risk of depression and cardiovascular comorbidities in Asian patients?
Hazard Ratio: 1.69 (95% CI 1.45–1.96)
Graves' disease is associated with an increased risk of depression and cardiovascular comorbidities, including diabetes and coronary artery disease, in Asian patients.
May prompt depression vigilance in Graves' disease; extends associations to Asian cohorts but remains hypothesis-generating.
BACKGROUND: This study aimed to evaluate the risk of depression and other cardiovascular comorbidities in Graves' disease (GD) patients in Asia. METHODS: The study patients were all newly diagnosed with GD [International Classification of Disease, 9th Revision, Clinical Modification (ICD-9-CM) 242.0] from January 1998 to December 2008. Patients aged <20 years or those with preexisting mental disorder (ICD-9-CM 290-319) were excluded from analyses. Control patients were randomly selected for the non-GD cohort, 1:4 frequency matched to the GD cohort according to sex, age and index year. The same exclusion criteria applied to the GD cohort were applied to the non-GD cohort. The GD cohort contained 4195 patients and the non-GD cohort contained 16 780 patients. RESULTS: The GD patients were more likely to have diabetes (8.03% vs. 4.48%, P < 0.0001), hypertension (18.1% vs. 13.5%, P < 0.0001), hyperlipidemia (11.9% vs. 9.09%, P < 0.0001) and coronary artery disease (10.3% vs. 5.86%, P < 0.0001) than the control patients were. The GD patients were also associated with significantly higher risk of depression than the control patients were (hazard ratio = 1.69, 95% confidence interval = 1.45-1.96). CONCLUSION: GD and GD treatment are associated with increased risk of depression diabetes and diabetic complications in Asian patients.
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Chen et al. (2014) conducted a cohort in Graves' disease (n=20,975). Graves' disease vs. Non-Graves' disease cohort was evaluated on depression (HR 1.69, 95% CI 1.45-1.96). Graves' disease was associated with a significantly higher risk of depression (HR 1.69; 95% CI 1.45-1.96) and higher rates of diabetes (8.03% vs 4.48%) compared to matched controls.
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