Key result
Endothelial colony-forming cells successfully formed a confluent and functional endothelium on human cell-derived tissue-engineered matrices, which was retained even after simulated transcatheter valve crimping procedures.
Why the study?
Cardiovascular implant hemocompatibility remains a major challenge lacking optimal antithrombotic properties, motivating pre-endothelialization of human-cell-derived tissue-engineered extracellular matrices to enhance hemocompatibility in next-generation heart valves.
Pre-endothelialization of human-cell-derived tissue-engineered extracellular matrices with endothelial-colony-forming cells is feasible and withstands crimping, offering a potential strategy to improve hemocompatibility of transcatheter heart valves.
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Pre-endothelialized hTEMs may enhance TEHV hemocompatibility; leaves open in vivo translation and antithrombotic therapy reduction.
Motta et al. (2022) studied Cardiovascular implant hemocompatibility. Endothelial colony-forming cells (ECFCs) seeding vs. HUVECs, gelatin-coated glass, and Collagen I gels was evaluated on Endothelialization, cell retention, and functionality after crimping. Endothelial colony-forming cells successfully formed a confluent and functional endothelium on human cell-derived tissue-engineered matrices, which was retained even after simulated transcatheter valve crimping procedures.