Key result
Pericardial drainage successfully treated a case of hemodynamically documented cardiac tamponade following cyclophosphamide therapy.
Case Report (n=1)
Pericardial drainage can be a life-saving and effective treatment for cardiac tamponade induced by cyclophosphamide therapy, challenging prior reports that it is not beneficial.
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Pericardial drainage resolved one cyclophosphamide-associated tamponade case; single report leaves open its broader role versus conservative care.
Cyclophosphamide in addition to total body irradiation is commonly used as preconditioning chemotherapy in patients undergoing bone marrow transplantation, but it may have deleterious consequences including myocardial failure and cardiac tamponade. Prior reports suggest that cardiac tamponade is usually fatal, and occurs approximately 2 weeks after initiation of therapy. Pericardiocentesis has previously been reported not to be beneficial. We describe the first case of hemodynamically documented cardiac tamponade after cyclophosphamide therapy that responded favorably to pericardial drainage. One should not be unduly discouraged, therefore, if this complication is suspected. Aggressive diagnosis and treatment seems indicated.
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Maloof et al. (1988) conducted a case report in Cardiac tamponade after cyclophosphamide therapy (n=1). Pericardial drainage was evaluated on Response to pericardial drainage. Pericardial drainage successfully treated a case of hemodynamically documented cardiac tamponade following cyclophosphamide therapy.
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