Key result
An optimized exponential drug release mode for drug-eluting stents led to a fairly uniform drug concentration distribution along the stent compared to a uniform release rate in a simulation model.
Computational modeling suggests that an exponential drug release mode for drug-eluting stents provides a more uniform drug distribution than a uniform release rate, potentially improving efficacy.
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Supports modeling of exponential stent release; leaves open clinical translation and human efficacy.
Local hemodynamic environment is a determinant factor in drug delivery from a drug eluting stent (DES) to the target arterial tissue. By using a simplified model of a DES, we demonstrated that if a DES had a drug release mode of uniform rate the drug released from the stent will distribute non-uniformly along the stent due to the flowing blood, with a significantly higher drug concentration at the distal part of the stent than that at the proximal one. This may explain why a DES could retard neointimal formation and vascular remodeling in downstream coronary segments. To solve this problem, we thereafter optimized the drug release mode of the DES as an exponential function. The simulation results showed that the optimized drug release mode could lead to a fairly uniform drug concentration distribution along the stent. Therefore, the present study suggested that to achieve a more effective result, optimization of drug eluting strategy (drug release mode) for the DES would be essential.
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Sun et al. (2015) studied this question. Optimized drug release mode (exponential function) vs. Uniform drug release mode was evaluated on Drug concentration distribution along the stent. An optimized exponential drug release mode for drug-eluting stents led to a fairly uniform drug concentration distribution along the stent compared to a uniform release rate in a simulation model.
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