A crucial administration timing separates between beneficial and counterproductive effects of opioids on postoperative pain

aInstitute of Pain Medicine, Rambam Health Care Campus, Haifa, Israel bFaculty of Social Welfare and Health Sciences, University of Haifa, Israel cThe Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel. *Corresponding author. Address: Institute of Pain Medicine, Rambam Health Care Campus, P.O. Box 9602, Haifa 31096, Israel. Tel.: +972 4 854193; fax: +972 4 8542880. E-mail address: [email protected] (E. Suzan). Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.