The synthesis of the 7-(2-deoxy-β-D-erythro-pentofuranosyl)adenine (1b) as well as the corresponding hypoxanthine- and purine nucleosides 3 and 4 is described employing the stereoselective nucleobase anion glycosylation. The N7/N9-isomer distribution of the 6-substituted purine (2-deoxyribonucleosides) depends on 6-substituent. Glycosyl transfer of 8a resulted in anomerization and yielded a mixture of the anomeric 6-methoxypurine N9-(2-deoxy-D-ribonucleosides) 7a/7d. The preferred glycosylic bond conformation of purine N7-(2-deoxyribonucleosides) is anti.
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Seela et al. (1995) studied this question.