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February 12, 2003BloodOpen Access

Recombinant factor VIIa enhances deposition of platelets with congenital or acquired αIIbβ3 deficiency to endothelial cell matrix and collagen under conditions of flow via tissue factor–independent thrombin generation

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Authors

TLTon LismanSMSultana MoschatsisJAJelle Adelmeijer

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Lisman et al. (2003) studied this question.

synapsesocial.com/papers/6a93bef2213a779dfe720e63https://doi.org/10.1182/blood-2002-09-2761
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The activation of factor X and prothrombin by recombinant factor VIIa in vivo is mediated by tissue factor.1993 · 198 citations
  2. 2Treatment of a Patient with Bernard-Soulier Syndrome and Recurrent Nosebleeds with Recombinant Factor VIIa1998 · 117 citations
  3. 3Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin1999 · 839 citations
  4. 4Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor.1988 · 235 citations
  5. 5Inhibition of fibrinolysis by recombinant factor VIIa in plasma from patients with severe hemophilia A2002 · 153 citations