Key result
The incidence of deep vein thrombosis in patients with acute ischemic stroke ranged from 0.53% to 19.8%, with elevated D-dimer, older age, female sex, lower limb plegia, and high NIHSS scores identified as the most frequent predictors.
Why the study?
Deep vein thrombosis is common during acute ischemic stroke, making risk stratification crucial for guiding diagnostic and treatment decisions.
What are the clinical and laboratory predictors of deep vein thrombosis in patients with acute ischemic stroke?
Systematic Review
What are the clinical and laboratory predictors of deep vein thrombosis in patients with acute ischemic stroke?
Identification of predictors such as D-dimer, age, and NIHSS scores can help stratify DVT risk in acute ischemic stroke patients for targeted thromboprophylaxis.
May aid DVT risk stratification in acute ischemic stroke; leaves open need for prospective validation.
Objective: In the acute stage of ischemic stroke, deep vein thrombosis (DVT) is more common than in the recovery stage. The stratification of the risk of developing DVT is crucial when making a decision in terms of correct diagnostic and treatment options in stroke patients. The aim of the study was to review systematically up-to-date published studies on predictors for DVT in patients with acute ischemic stroke. Methods: Study design -systematic review of observational studies. Russian scientific citation database of RSCI, English scientific citation database of PubMed, Web of Science, Embase for the period of time 2018-August 2023 were used for studies search. Data from selected studies were extracted, including study design, data source, outcome definition, sample size, and predictors. The most common demographic, clinical and/or laboratory markers for predicting stroke-related DVT were presented. Results: Totally 234 studies were reviewed, and after the selection process, nine studies were included in this article. The incidence of DVT in patients with acute ischemic stroke ranged from 0.53 % to 19.8 %. The most frequently pointed predictors were D-dimer level, age, sex, lower limb plegia, and high NIHHS scores. Conclusion: Identification of individuals with high risk of venous limb thrombosis after ischemic stroke is crucial for targeted thromboprophylaxis. Advanced knowledge of predictors and biomarkers is needed to guide clinical decision-making and develop risk prediction models.
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Torokulova et al. (2024) conducted a systematic review in Acute ischemic stroke. Predictors of deep vein thrombosis (e.g., D-dimer, age, sex, lower limb plegia, high NIHSS scores) was evaluated on Incidence and predictors of deep vein thrombosis. The incidence of deep vein thrombosis in patients with acute ischemic stroke ranged from 0.53% to 19.8%, with elevated D-dimer, older age, female sex, lower limb plegia, and high NIHSS scores identified as the most frequent predictors.
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