Key result
A ceramic heart valve demonstrated promising blood compatibility in 5 sheep over 20-35 days and high durability under pulsatile conditions.
Why the study?
Does a ceramic heart valve demonstrate blood compatibility and durability in a sheep model and in vitro testing?
Does a ceramic heart valve demonstrate blood compatibility and durability in a sheep model and in vitro testing?
A novel ceramic heart valve demonstrated promising thromboresistance in a sheep model and high durability in vitro, suggesting potential as an artificial heart valve.
No immediate clinical role; leaves open translation of ceramic valves to human implants.
A durable and thromboresistant ceramic heart valve comprised of a single crystal alumina disk and titanium nitride (TiN) valve ring has been developed. Blood compatibility was examined by scanning electron microscopy (SEM) examinations of the valves implanted in sheep for 35 (#1), 26 (#2), 20 (#3), 23 (#4), and 26 (#5) days. The single crystal alumina and TiN surfaces were free of platelet aggregation or fibrin networks, except for some depositions of fibrin and platelets on the outflow TiN ring in #3, and isolated red cells on the outflow TiN ring in #5. Durability testing under high pressure (1750 mmHg = 233 KPa) pulsatile conditions showed that the safety factor of the ceramic valve was more than seven times greater than anticipated. The ceramic valve is promising as an artificial heart valve.
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Mitamura et al. (1989) studied this question. Ceramic heart valve was evaluated on Blood compatibility and durability. A ceramic heart valve demonstrated promising blood compatibility in 5 sheep over 20-35 days and high durability under pulsatile conditions.
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