Nuclear Overhauser effect (NOE) measurements are reported for the nonexchangeable base and ribose 1' proton resonances of CCGGAp, ACCGGp, and ACCGGUp. The results permit assignment of these resonances to particular nucleotides in the sequences. The NOE data rule out conformations containing syn glycosidic linkages and conformations in which the purine 8 and pyrimidine 6 protons are closer to the 3' nearest-neighbor ribose 1' proton than to the 5' nearest-neighbor ribose 1' proton.
No takes yet. Share an insight, caveat, or question.
Petersheim et al. (1983) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: