Key result
Most bacteriologically sterile otitis media exudates inhibited the cytopathogenicity of herpes simplex, poliomyelitis, and adenoviruses in HeLa cell cultures.
Sterile otitis media exudates inhibit the cytopathogenicity of several viruses in HeLa cell cultures.
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May indicate in vitro antiviral activity in exudates; leaves open clinical relevance and requires in vivo confirmation.
The inhibitory effect of bacteriologically sterile otitis media exudates on multiplication of three types of viruses was studied. Most of the exudates tested were found to have an inhibitory effect on cytopathogenicity of these viruses in HeLa cell cultures.
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Shrala et al. (1961) studied this question. Most bacteriologically sterile otitis media exudates inhibited the cytopathogenicity of herpes simplex, poliomyelitis, and adenoviruses in HeLa cell cultures.
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