January 13, 2007AJP Heart and Circulatory Physiology
Restoration of coronary endothelial function in obese Zucker rats by a low-carbohydrate diet
Key result
A low-carbohydrate diet restored obesity-induced impairment in endothelium-dependent vasodilation of coronary arterioles in male Zucker rats, likely via a hyperpolarizing factor independent of NO.
Why the study?
Does a low-carbohydrate diet improve coronary endothelial function in obese Zucker rats?
Population
Male Zucker rats (lean and obese)
Comparison
Low-carbohydrate diet fed ad libitum for 3 weeks vs Normal diet
Design
Preclinical
Follow-up
3 weeks
Authors
Discussion
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Member takes
Implication
Should not change clinical practice in obesity; leaves open translation of coronary endothelial effects to humans.
Structured PICO
Does a low-carbohydrate diet improve coronary endothelial function in obese Zucker rats?
P
Population
Male Zucker rats (lean and obese) fed normal or low-carbohydrate diets for 3 weeks to assess coronary endothelial function.
I
Intervention
Low-carbohydrate diet fed ad libitum for 3 weeks
C
Comparator
Normal diet
O
Outcome
Coronary endothelial and vascular function (assessed by diameter measurements of cannulated and pressurized coronary arterioles during administration of acetylcholine, sodium nitroprusside, or flow)surrogate
A low-carbohydrate diet restores obesity-induced impairment in coronary endothelial function in rats, likely via a hyperpolarizing factor independent of nitric oxide.
Cite This Study
Focardi et al. (2007) studied Obesity-induced impairment in coronary endothelial function. Low-carbohydrate diet vs. Normal diet was evaluated on Endothelium-dependent acetylcholine-induced vasodilation and flow-induced dilation. A low-carbohydrate diet restored obesity-induced impairment in endothelium-dependent vasodilation of coronary arterioles in male Zucker rats, likely via a hyperpolarizing factor independent of NO.