Effects of Bleomycin on Mouse Transplantable Tumors

The present paper briefly considers the effect of a new antitumor antibiotic, bleomycin1), on several strains of transplantable mouse ascites tumors, all of which were originally established as syngeneic in tumor-host relationship. The antibiotic showed moderate to marked effects upon Rous sarcoma virusinduced mouse ascites sarcoma at fairly wide dose level, particularly when F1 hybrid mice were employed as host animals. It gave, however, almost no effect upon virus-producing Friend ascites tumor and mouse ascites plasmacytoma.