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The agent isolated by Chandler in mice inoculated intracerebrally with brain tissue from goats affected with experimental scrapie can be passed serially in mice by this route. In the Rocky Mountain Laboratory stock of Swiss mice it causes a relentlessly progressive, and invariably fatal, disease of the central nervous system, usually after an incubation period of 4 to 5 months. The disease is characterized clinically by incoordination of gait, muscular atrophy, and drowsiness and neuropathologically by prominent astrocytosis, degeneration of neurons, and spongy alteration of the neuroparenchyma.
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Eklund et al. (1963) studied this question.
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