Key result
Methoxamine, mephentermine, and metaraminol had less tendency to increase vulnerability to fibrillation than levarterenol under conditions of multiple stimuli stress.
Population
Experimental heart model subjected to successive stimuli at various ectopic foci
Comparison
Sympathomimetic pressor drugs vs Normal circumstances and comparison between…
Design
Preclinical
Authors
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May guide vasopressor selection under arrhythmic stress; animal data leave clinical translation open.
Methoxamine, mephentermine, and metaraminol are less arrhythmogenic than levarterenol under stress from multiple ectopic stimuli.
Gilbert et al. (1959) studied Arrhythmias. Sympathomimetic pressor drugs (Methoxamine, mephentermine, metaraminol) vs. Levarterenol was evaluated on Vulnerability to fibrillation. Methoxamine, mephentermine, and metaraminol had less tendency to increase vulnerability to fibrillation than levarterenol under conditions of multiple stimuli stress.
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