Studies on the Creatinuria Due to Methylated Steroids 1

We reported in 1941 that the oral administration of methyl testosterone caused a. marked increase of creatine excretion in sexually undeveloped dwarfs (1). Simultaneously, Samuels, Henschel, and Keys (2) discovered that the same effects occurred in normal men. Since then Tager (3), Werner and West (4), and others (5, 6, 7) have observed that creatinuria followed the use of methyl testosterone in various conditions. The present paper deals with further studies we have made to determine the nature of the changes which occur in the creatinecreatinine metabolism.