Anomalous Serum Concentrations of Digoxin

Letters and Corrections1 August 1983Anomalous Serum Concentrations of DigoxinPAUL E. ROLAN, M.D., B.S., DEREK B. FREWIN, M.D., STEPHEN R. HAGLEYPAUL E. ROLAN, M.D., B.S.Search for more papers by this author, DEREK B. FREWIN, M.D.Search for more papers by this author, STEPHEN R. HAGLEYSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-99-2-280_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: We read with interest Craver and Valdes' report (1) of a patient with renal failure in whom serum digoxin continued to rise despite cessation of therapy. We have seen a similar phenomenon in a 75-year-old man, who was admitted to the hospital with multiple trauma and subsequently developed acute renal and hepatic failure. The patient was not on maintenance digoxin. He was given a total of 1 mg digoxin intravenously, in two doses. All of the five serum digoxin estimations in the next 10 days were above the therapeutic range of 0.6 to 2.3 nmol/litre. The highest...References1. CRAVER J and VALDES R. Anomalous serum digoxin concentrations in uremia. Ann Intern Med. 1983;98:483-4. AbstractGoogle Scholar2. ARONSON J and GRAHAME-SMITH D. Altered distribution of digoxin in renal failure—a cause of digoxin toxicity? Br J Clin Pharm. 1976;3:1045-51. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PAUL E. ROLAN, M.D., B.S.; DEREK B. FREWIN, M.D.; STEPHEN R. HAGLEYAffiliations: Box 498, G.P.O. The University of Adelaide Adelaide, South Australia 5001 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDelayed digoxin toxicity following discontinuance in acute renal failure 1 August 1983Volume 99, Issue 2Page: 280-280KeywordsAcute renal failureAttentionRenal failure ePublished: 1 December 2008 Issue Published: 1 August 1983 PDF downloadLoading ...