Key result
Nighttime dosing of digoxin (after 1700) eliminated inappropriate therapeutic drug monitoring tests, whereas 52% of tests overall were drawn inappropriately within 6 hours of the last dose.
Why the study?
Does nighttime dosing of digoxin prevent inappropriate early sampling for therapeutic drug monitoring in outpatients?
Population
86 outpatients who had serum digoxin determinations between April 10 and April 28, 1992 (585 tests)
Comparison
Nighttime dosing of digoxin (after 1700) vs Daytime or variable dosing of digoxin
Design
Cross-sectional
Authors
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May warrant consideration of nighttime dosing to improve digoxin TDM reliability; leaves open need for prospective outcome validation.
Observational (n=86)
No
Does nighttime dosing of digoxin prevent inappropriate early sampling for therapeutic drug monitoring in outpatients?
Nighttime dosing of digoxin ensures that therapeutic drug monitoring samples are drawn post-distribution, avoiding clinically uninterpretable results.
Bernard et al. (1996) conducted an observational in Outpatients requiring therapeutic drug monitoring of digoxin (n=86). Nighttime dosing of digoxin (after 1700) vs. Daytime dosing was evaluated on Inappropriate samples drawn within 6 h of the last dose. Nighttime dosing of digoxin (after 1700) eliminated inappropriate therapeutic drug monitoring tests, whereas 52% of tests overall were drawn inappropriately within 6 hours of the last dose.
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