Key result
Plasma natriuretic activity evoked by saline infusion or oxytocin analogs in cows and dogs was separated into a fraction of approximately 1000 molecular weight, suggesting it is a polypeptide.
The study identifies a polypeptide-like plasma natriuretic factor (MW ~1000) released in response to saline infusion or oxytocin analogs in animal models.
Animal findings offer no basis for human volume management; leaves open a ~1000 MW natriuretic polypeptide as a research target.
Plasma natriuretic activity was evoked in cows and dogs by infusion of saline with or without dextran. Deproteinized samples were fractionated on both Sephadex and Bio-Gel columns; the activity was separated, the approximate molecular weight being in the region of 1000. Incubation with chymotrypsin destroyed the activity, suggesting that it might be a polypeptide. A similar activity in blood resulted from intracarotid injection of either oxytocin or either of two synthetic analogs. Possibly the latter are saluretic by virtue of a releasing action on some intracranial structure for another natriuretic peptide.
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Sedlákova et al. (1969) studied this question. Saline infusion and intracarotid injection of oxytocin or synthetic analogs was evaluated on Plasma natriuretic activity. Plasma natriuretic activity evoked by saline infusion or oxytocin analogs in cows and dogs was separated into a fraction of approximately 1000 molecular weight, suggesting it is a polypeptide.
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