Key result
Intraperitoneally administered dextran 70 is a clinically useful marker for the description of fluid kinetics in CAPD patients under various conditions.
Why the study?
What is the most useful intraperitoneally administered macromolecule for determining fluid kinetics in CAPD patients?
What is the most useful intraperitoneally administered macromolecule for determining fluid kinetics in CAPD patients?
Dextran 70 is identified as a clinically useful marker for assessing fluid kinetics in CAPD patients under various conditions.
Dextran 70 may aid CAPD fluid kinetic assessments; leaves open the optimal macromolecule without prospective comparative trials.
A review is given on various aspects of using the disappearance rate of intraperitoneally administered macromolecules for the determination of fluid kinetics in CAPD patients. The rationale and mathematics for the calculation of transcapillary ultrafiltration and of indirect measurement of lymphatic absorption are described. A comparison is made between autologous haemoglobin, human albumin and dextran 70. Dextran 70 appeared most useful; one brand of human albumin increased solute transport. Lymphatic absorption was higher after the installation of a 3-litre dialysate volume than after a 2-litre one, and also higher during peritonitis than after recovery from infection. A gradual increase in intraperitoneal volume, as obtained with glucose 3.86% dialysate, had no apparent effect on the disappearance rate of dextran 70. It is concluded that intraperitoneally administered dextran 70 is a clinically useful marker for the description of fluid kinetics in CAPD patients under various conditions.
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Krediet et al. (2008) conducted a review in Continuous Ambulatory Peritoneal Dialysis (CAPD). Intraperitoneally administered macromolecules (e.g., dextran 70) was evaluated on Fluid kinetics (transcapillary ultrafiltration and lymphatic absorption). Intraperitoneally administered dextran 70 is a clinically useful marker for the description of fluid kinetics in CAPD patients under various conditions.
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