What is the clinical evidence from this study?

Study design: Other. Population: Coronary artery constriction (experimental model) (n=104). Intervention: Coronary artery constriction vs. Unconstricted state.

January 1, 1975Japanese Heart JournalOpen Access

Cyclic Fluctuations in Coronary Blood Pressure and Flow Induced by Coronary Artery Constriction

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Key result

Partial constriction of the coronary artery in dogs induced slow cyclic fluctuations in blood pressure and flow accompanied by ischemic ECG changes, which were eliminated by nitroglycerin.

Population

Anesthetized dogs with partially constricted coronary arteries

Design

Preclinical

Authors

YUYasumi UchidaTsukuba Memorial Hospital NYNobuo YoshimotoSaitama Medical University SMSatoru MuraoThe University of Tokyo

Discussion

Member takes

Implication

Nitroglycerin-responsive cyclic ischemia in this canine model warrants mechanistic follow-up; leaves open human translation.

Structured PICO

Population

104 adult mongrel dogs subjected to experimental coronary artery constriction to evaluate cyclic fluctuations in coronary blood pressure and flow.

Intervention

Partial coronary artery constriction (lowering mean peripheral coronary blood pressure below 50% of control) and subsequent pharmacological or surgical interventions (nitroglycerin, phentolamine, propranolol, atropine, cervical vagotomy, stellectomy)

Outcome

Cyclic fluctuations in coronary blood pressure and coronary blood flowsurrogate

In a canine model, cyclic fluctuations in coronary hemodynamics induced by severe coronary constriction were reversed by nitroglycerin but unaffected by autonomic blockade.

Limitations

Animal model, so exact clinical applicability to human variant angina remains to be elucidated.

Cite This Study

Uchida et al. (1975) studied Coronary artery constriction (experimental model) (n=104). Coronary artery constriction vs. Unconstricted state was evaluated. Partial constriction of the coronary artery in dogs induced slow cyclic fluctuations in blood pressure and flow accompanied by ischemic ECG changes, which were eliminated by nitroglycerin.

synapsesocial.com/papers/6a93c833d26e0e58207c2d2a https://doi.org/10.1536/ihj.16.454

View Full Paper

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January 1, 1975Japanese Heart JournalOpen Access

Cyclic Fluctuations in Coronary Blood Pressure and Flow Induced by Coronary Artery Constriction

View Full Paper

Ask AI

Bookmark

Key result

Partial constriction of the coronary artery in dogs induced slow cyclic fluctuations in blood pressure and flow accompanied by ischemic ECG changes, which were eliminated by nitroglycerin.

Population

Anesthetized dogs with partially constricted coronary arteries

Design

Preclinical

Authors

YUYasumi UchidaTsukuba Memorial Hospital NYNobuo YoshimotoSaitama Medical University SMSatoru MuraoThe University of Tokyo

Discussion

Member takes

Implication

Nitroglycerin-responsive cyclic ischemia in this canine model warrants mechanistic follow-up; leaves open human translation.

Structured PICO

Population

104 adult mongrel dogs subjected to experimental coronary artery constriction to evaluate cyclic fluctuations in coronary blood pressure and flow.

Intervention

Outcome

Cyclic fluctuations in coronary blood pressure and coronary blood flowsurrogate

In a canine model, cyclic fluctuations in coronary hemodynamics induced by severe coronary constriction were reversed by nitroglycerin but unaffected by autonomic blockade.

Limitations

Animal model, so exact clinical applicability to human variant angina remains to be elucidated.

Cite This Study

synapsesocial.com/papers/6a93c833d26e0e58207c2d2a https://doi.org/10.1536/ihj.16.454

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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