The role of the liver in the excretion and destruction of digitoxin was studied in the rat, rabbit, dog and man (in part). It was found that no more than 10 per cent of a given dose of digitoxin is excreted in the bile of the animals tested and none could be detected in the bile of two human subjects. Evidence was obtained which suggested that in the rat and rabbit, the liver was able to destroy a large amount of injected digitoxin.
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George et al. (1952) studied this question.
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