The nature of digitoxin fixation in isolated hearts was studied with C 14 labelled digitoxin. Fixation was greatest in the early stages of perfusion. The amount of drug fixed was measured directly. A considerable percentage of the digitoxin in cardiac muscle was changed to other substances. These substances are more firmly bound to the heart than digitoxin.
No takes yet. Share an insight, caveat, or question.
Sjoerdsma et al. (1951) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: