What question did this study set out to answer?

To identify the primary arterial and flow parameters that determine aortic systolic, diastolic, and pulse pressures.

September 1, 1998HypertensionOpen Access

Determinants of Pulse Pressure

Q: What is the clinical evidence from this study?

Intervention: 2-element windkessel model prediction vs. Measured systolic and diastolic pressures. Primary outcome: Predicted systolic and diastolic pressures compared with measured pressures (r=0.958 for systolic, r=0.995 for diastolic).

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Key result

For a given aortic flow, total arterial resistance and total arterial compliance in a 2-element windkessel model accurately predicted systolic (r=0.958) and diastolic (r=0.995) aortic pressures in dogs.

Authors

NWNico WesterhofVascular Medicine

Discussion

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Implication

Validates 2-element Windkessel for pressure prediction from flow in dogs; leaves open translation to human hypertension hemodynamics.

Key Points

To identify the primary arterial and flow parameters that determine aortic systolic, diastolic, and pulse pressures.
Evaluated 7 dogs under control conditions and during mechanical occlusions at 4 aortic locations and bilateral carotid arteries.
Applied measured aortic flow to a 2-element Windkessel model incorporating peripheral resistance and total arterial compliance derived from diastolic decay time.
Predicted systolic and diastolic pressures matched experimental measurements closely across all occlusion conditions: Ps,wk = (1.000 ± 0.0055) Ps (r = 0.958) and Pd,wk = (1.024 ± 0.0035) Pd (r = 0.995).
Pulse pressure predictions achieved strong correlation with measured values (PPwk = [0.99 ± 0.016] PP, r = 0.911), whereas multiple regression of pulse pressure against resistance and compliance alone yielded R² = 0.19.

PICO

Population

7 dogs studied under control conditions and during aortic or carotid artery occlusion to determine arterial parameters of pulse pressure.

Exposure / Comparator

2-element windkessel model prediction vs Measured systolic and diastolic pressures

Primary Outcome

Predicted systolic and diastolic pressures compared with measured pressures — r=0.958 for systolic, r=0.995 for diastolic

Main Result

Effect estimate: r=0.958 for systolic, r=0.995 for diastolic

Cite This Study

Nico Westerhof (1998) studied this question. 2-element windkessel model prediction vs. Measured systolic and diastolic pressures was evaluated on Predicted systolic and diastolic pressures compared with measured pressures (r=0.958 for systolic, r=0.995 for diastolic). For a given aortic flow, total arterial resistance and total arterial compliance in a 2-element windkessel model accurately predicted systolic (r=0.958) and diastolic (r=0.995) aortic pressures in dogs.

synapsesocial.com/papers/6a93ca3f0bf5a04cbf7c2f83 https://doi.org/10.1161/01.hyp.32.3.556

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Determinants of Pulse Pressure

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Implication

Key Points

PICO

Main Result

Cite This Study

Determinants of Pulse Pressure

Discussion

Member takes

Implication

Key Points

PICO

Main Result

Cite This Study

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