Key result
Anthracycline exposure in female breast cancer patients resulted in a ≥10% relative reduction in right ventricular global longitudinal strain in 75% of patients.
Why the study?
RV function is an independent factor for cardiac outcomes, but data evaluating RV GLS following anthracycline therapy are limited.
Does anthracycline therapy reduce right ventricle global longitudinal strain in female patients with breast cancer?
Cohort (n=40)
Does anthracycline therapy reduce right ventricle global longitudinal strain in female patients with breast cancer?
Subclinical right ventricular dysfunction, measured by strain, is highly prevalent following anthracycline therapy even when left ventricular function remains within normal limits.
Answers are grounded in this paper and cite their sources.
RV GLS decline after anthracyclines despite preserved LV function warrants monitoring caution; leaves open its prognostic value in cardio-oncology.
Background: Anthracycline (ANT) is the most recognized therapy known to cause cardiotoxicity, mainly left ventricle (LV) dysfunction. Global Longitudinal Strain (GLS) is the optimal tool for assessment of subclinical LV dysfunction. Right ventricle (RV) function has been recognized as an independent factor for cardiac outcomes; however, data evaluating RV GLS is limited. We aimed to evaluate the change in RV GLS following ANT therapy. Methods: The study cohort is part of the Israel Cardio-Oncology Registry (ICOR). All patients performed echocardiography before (T1) and at the end (T3) of ANT therapy. A significant reduction was defined as a relative reduction of ≥10% in RV GLS values. Results: The study included 40 female patients with breast cancer treated with ANT. During follow-up, both RV GLS and free wall longitudinal strain systolic peak (RV FWLS PK) decreased significantly (p < 0.001 and p = 0.002). Altogether, 30 (75%) and 23 (58%) patients showed RV GLS and RV FWLS PK ≥ 10% relative reduction. At T3, LV ejection fraction and LV GLS were within normal range. Conclusions: RV GLS and RV FWLS PK reduction following ANT exposure is extremely frequent, comparing to LV GLS reduction.
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Laufer‐Perl et al. (2022) conducted a cohort in Breast cancer (n=40). Anthracycline therapy vs. Baseline (before therapy) was evaluated on Relative reduction of ≥10% in right ventricular global longitudinal strain (RV GLS) (p=<0.001). Anthracycline exposure in female breast cancer patients resulted in a ≥10% relative reduction in right ventricular global longitudinal strain in 75% of patients.
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