Key result
Interferon protected cells against viral cytopathogenic effects only at a multiplicity of infection of 1 or less, and this protection was transient, ultimately leading to cell death.
Population
Cells infected with vaccinia, herpes, Echo or vesicular stomatitis virus
Comparison
Interferon treatment vs Different levels of input multiplicity of…
Design
Preclinical
Authors
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Transient interferon protection at low viral loads fails to prevent cell death; hypothesis-generating for antiviral strategies, requiring in vivo validation.
Interferon treatment only transiently protects cells from viral cytopathogenic effects at low multiplicity of infection, ultimately only delaying cell death.
Stitz et al. (1980) studied Viral infection (vaccinia, herpes, Echo, vesicular stomatitis virus). Interferon was evaluated on Protection against cytopathogenic effect. Interferon protected cells against viral cytopathogenic effects only at a multiplicity of infection of 1 or less, and this protection was transient, ultimately leading to cell death.
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