Nanoparticles on demand: Upon the site-specific covalent attachment of hydrophobic molecules to one end of the biopolymer backbone, chimeric polypeptides (derived from elastin-like polypeptides) can self-assemble to form thermoresponsive nanoparticles suitable for drug delivery. Molecules with a distribution coefficient greater than 1.5 imparted sufficient amphiphilicity to drive self-assembly into sub-100 nm nanoparticles (see picture).
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McDaniel et al. (2012) studied this question.
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