Key result
Systemic injection of LPS in rats increased NLCI and decreased CVC over 3 days, with repeated measures showing a low coefficient of variation (<0.2) at each time point.
Why the study?
Biometrics of common physiologic signals can reflect health status, leading to the hypothesis that measures of ventilatory pattern variability and cardioventilatory coupling are sensitive to endotoxemia-evoked neuroinflammation.
Does LPS-induced systemic inflammation alter ventilatory pattern variability and cardioventilatory coupling in rats?
Population
Sprague Dawley male rats (n = 8 LPS, n = 3 PBS)
Comparison
Intraperitoneal lipopolysaccharide (LPS) vs phosphate buffered saline (PBS) on 3 consecutive days
Design
Preclinical experimental animal study
Follow-up
4–6 h after injection on 3 consecutive days
Authors
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NLCI tracks inflammation-driven ventilatory changes in rats; hypothesis-generating for human biometric monitoring.
Does LPS-induced systemic inflammation alter ventilatory pattern variability and cardioventilatory coupling in rats?
Systemic inflammation induced by LPS in rats alters ventilatory pattern variability and cardioventilatory coupling, suggesting these metrics reflect inflammatory effects on respiratory networks.
Campanaro et al. (2023) studied Systemic inflammation (n=11). Lipopolysaccharide (LPS) vs. Phosphate buffered saline (PBS) was evaluated on Nonlinear Complexity Index (NLCI) and cardioventilatory coupling (CVC). Systemic injection of LPS in rats increased NLCI and decreased CVC over 3 days, with repeated measures showing a low coefficient of variation (<0.2) at each time point.
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