Key result
BS-C-1 cells were suitable for plaque assays of polio and measles viruses, with low-passage cells recommended for titration due to higher poliovirus susceptibility.
Low-passage BS-C-1 cells are recommended for the titration of polio and measles viruses due to higher susceptibility.
May guide cell selection for viral assays in research labs; leaves open validation before diagnostic standardization.
BS-C-1 cells, cultivated in a simple medium designated M-E, were found to be suitable for a plaque assay of polio and measles viruses. In the plaque assay both low- and high-passage levels of the BS-C-1 cell line were highly susceptible to measles virus but titers of polioviruses were lower in the high-passage cells. Low-passage cells, preserved and stored at −196 °C for prolonged periods, are recommended for the titration of polio and measles viruses.
No takes yet. Share an insight, caveat, or question.
Furesz et al. (1965) studied Polio and measles virus infection (in vitro). BS-C-1 cells (low- and high-passage levels) was evaluated on Plaque assay suitability and viral titers. BS-C-1 cells were suitable for plaque assays of polio and measles viruses, with low-passage cells recommended for titration due to higher poliovirus susceptibility.