It is well established that Freund's complete adjuvant composed of heat-killed mycobacterial cells and mineral oil is the most potent adjuvant for the induction of cellmediated immunity to soluble antigens Previously, the authors Data accumulated recently suggest that cell walls not only of mycobacteria but also of other bacteria such as Streptococcus, Staphylococcus, Bacillus, Escherichia, Neisseria, Moraxella and Proteus are active as adjuvants for the induction of circulating antibodies and delayed type hypersensitivity in guinea pigs
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Azuma et al. (1976) studied this question.
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