Key result
Testosterone was significantly positively associated with carotid artery distensibility (β-estimate = 0.04, P = 0.0005) among HIV-infected premenopausal women.
Why the study?
Are sex hormone and gonadotropin concentrations associated with subclinical atherosclerosis in HIV-infected and -uninfected premenopausal women?
Population
1094 premenopausal women (771 HIV infected, 323 HIV uninfected) in the Women's Interagency HIV Study (WIHS)
Comparison
Endogenous sex hormone and gonadotropin… vs HIV-uninfected women; varying levels of…
Design
Cross-sectional
Authors
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May link testosterone to vascular compliance in HIV-infected women; hypothesis-generating and leaves open need for longitudinal confirmation.
Cross-Sectional (n=1,094)
Are sex hormone and gonadotropin concentrations associated with subclinical atherosclerosis in HIV-infected and -uninfected premenopausal women?
Effect estimate: β-estimate 0.04
p-value: p=0.0005
In premenopausal women with HIV, testosterone deficiency is linked to increased carotid artery stiffness, and estradiol deficiency is linked to stiffness in those with severe immunosuppression.
Karim et al. (2013) conducted a cross-sectional in HIV infection (n=1,094). Sex hormone and gonadotropin concentrations vs. HIV-uninfected women was evaluated on carotid artery intima-media thickness and distensibility (β-estimate 0.04, p=0.0005). Testosterone was significantly positively associated with carotid artery distensibility (β-estimate = 0.04, P = 0.0005) among HIV-infected premenopausal women.
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