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Serum gastrin has been determined by radioimmunoassay in 13 subjects free of gastrointestinal disease, in the basal state, and following the intravenous injection of 1 mg glucagon. Serum gastrin fell from a mean +/- SEM level of 50.3 +/- 6.7 to 9.4 +/- 3.3 pg/ml at 30 minutes after injection, significant at p<0.005. This is similar to the response previously reported for secretin and indicates a role for glucagon in the control of gastrin release.
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Hansky et al. (1973) studied this question.
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