The Mutual Influence of Gastrin and Secretin on the External Pancreatic Secretion in Dogs

The external pancreatic secretion of fluid, bicarbonate and protein in 4 dogs with Thomas type fistulae, has been studied in response to secretin (1 U/kg b.w.), gastrin (2 U/kg b.w.) and combined secretin–gastrin stimulation. Gastrin exerted a stimulating effect on the pancreatic secretion of fluid, bicarbonate and protein and increased the bicarbonate concentration in the juice significantly above basal level. The combined effect of secretin and gastrin on the secretion of fluid, bicarbonate and protein did not differ from the summarized effect of the two agents given separately. Potentation between secretin and gastrin was not demonstrated.