The study of specifically labeled alkoxides generated in the gas phase by deprotonation of epimeric norbernols demonstrates, beyond any doubt, that ‘solvated’ hydride ions are formed as intermediates in the course of enolate formation. Kinetic isotope effects and exo/endo‐face selectivities for the dehydrogenation are discussed.
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Dreyer et al. (1990) studied this question.
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