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An optimized cyclic peptidomimetic (see picture) of the NPNA-repeat region in the circumsporozoite (CS) protein of P. falciparum was designed. When delivered to the immune system on human-compatible viruslike particles (virosomes), the mimetic effectively elicits sporozoite-binding antibodies. This virosome-mimotope (virotope) approach may be of general value for the design and testing of new synthetic-vaccine candidates.
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Pfeiffer et al. (2003) studied this question.
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