The problem of water retention in liver disease has been approached through both clinical and animal studies. In clinical studies Aldersberg and Fox (1943) found an abnormal retention of water when water tolerance tests were performed on patients with severe parenchymatous liver disease and recently Ralli et al. (1945) have demonstrated antidiuretic activity in urines from patients with hepatic cirrhosis and ascites. With respect to animal studies Aldersberg and Fox (1943) observed abnormal water tolerance tests in dogs when the liver was injured by phosphorus and histamine. Shay, Kolm, and Fels (1945) also reported the occurrence of abnormal water tolerance tests in rats fed a high fat diet. Leslie and Ralli (1947) have recently found that rats fed a high fat-low protein diet showed a decreased urine output during water tolerance tests, and they observed that the urines from such rats had antidiuretic activity.
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Hall et al. (1949) studied this question.