Fixed chirality: The treatment of cyclooctapyrroles (see picture) with a metal source with optically active carboxylate or amine ligands leads to enantioselective metalation to give stereochemically stable helical mononuclear and dinuclear complexes without a chiral auxiliary. The helicity of the dicopper complex was determined by the simulation of the CD spectrum on the basis of X-ray crystallographic data.
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Setsune et al. (2008) studied this question.
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