Efficient Synthesis of a Conformationally Rigid Polymer Based on myo-Inositol Carbonate

Compounds having three syn-axial hydroxyl groups on a six membered ring draw an interest due to their ability to form complexes with many cations. 1,2 The steric require-ments of the cyclohexane polyols to form complexes with cations are, however, rather strict and only a few such compounds with three syn-axial hydroxyls, including cis-inositol, were known. 3-8 Moreover, none of these compounds is readily available, especially in large scales. Recently, synthesis of the readily available myo-inositol 4,6-carbonate 1 with three hydroxyl groups at the axial position on a cyclohexane was reported.