Answers are grounded in this paper and cite their sources.
The effect of polyamines on the ability of calcium-dependent soluble rat brain phosphatidylinositol-phosphodiesterase to hydrolyze dispersed phosphatidylinositol was examined. Putrescine and cadaverine stimulated activity at all concentrations tested. In contrast, spermine and spermidine stimulated the reaction slightly at low concentrations but caused progressively greater inhibition as their levels were further increased. Phosphatidylinositol hydrolysis was inhibited by several multivalent cations, especially lanthanum and manganese. Spermidine partially replaced the calcium requirement of the enzyme. The possibility that polyamines may play a role in the regulation in vivo of phosphatidylinositol-phosphodiesterase is discussed.
No takes yet. Share an insight, caveat, or question.
Eichberg et al. (1981) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: