Key result
Obesity was associated with significantly increased serum MMP-8 levels compared to normal weight individuals (P=0.0031), which may contribute to insulin resistance.
Why the study?
Is obesity associated with elevated circulating MMP-8, and does MMP-8 cleave the insulin receptor?
Observational (n=240)
Is obesity associated with elevated circulating MMP-8, and does MMP-8 cleave the insulin receptor?
p-value: p=0.0031
Elevated MMP-8 in obesity and smoking may contribute to insulin resistance by cleaving the insulin receptor, suggesting a potential therapeutic target.
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Obesity is associated with elevated MMP-8; leaves open its contribution to insulin resistance via receptor cleavage and therapeutic potential.
Lauhio et al. (2016) conducted an observational in Obesity (n=240). Obesity vs. Normal weight was evaluated on Serum MMP-8 levels (p=0.0031). Obesity was associated with significantly increased serum MMP-8 levels compared to normal weight individuals (P=0.0031), which may contribute to insulin resistance.
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