Specific Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mediated by Soulattrolide, a Coumarin Isolated from the Latex of Calophyllum teysmannii

Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.